1. Unexplained Fatigue

Feeling tired after a long day is normal. But when you’re dragging your feet for no clear reason, even after a full night’s sleep, your body might be trying to warn you. Fatigue is one of the most overlooked symptoms of heart disease, especially in women. It can happen when your heart isn’t pumping efficiently, leaving your muscles and organs under-supplied with oxygen-rich blood.
This type of tiredness doesn’t go away with rest. It’s the kind that makes routine tasks feel exhausting, like climbing stairs or carrying groceries. You might think it’s burnout or age, but if fatigue is lingering and you can’t explain it, it’s worth checking in with your doctor. According to the American Heart Association, persistent fatigue may be a sign of heart failure or coronary artery disease.
2. Shortness of Breath During Mild Activity
Out of breath after chasing your kid or walking up a flight of stairs? It might not just be your fitness level. Sudden or progressive shortness of breath, even during light activities, is often a red flag for underlying heart disease. It can signal that your heart isn’t moving blood effectively, leading to a backup in the lungs.
This symptom tends to sneak up gradually, so it’s easy to brush off. But if you’re breathing harder than usual doing things you’ve always done without trouble, it’s time to pay attention. It could be a sign of congestive heart failure or a valve issue. Many people, especially those in their 40s and 50s, assume they’re just getting older. But don’t underestimate this one.
3. Jaw, Neck, or Back Discomfort
We tend to associate heart pain with a crushing feeling in the chest, but that’s not always where it shows up. Sometimes, the discomfort creeps into the jaw, neck, or upper back. These areas share nerve pathways with the heart, which is why pain can be referred there. For women especially, heart-related pain often shows up in less obvious places.
This type of pain might come and go, feel like a dull ache, or even mimic muscle strain. If there’s no injury or other clear explanation, it could be a sign of angina, which happens when blood flow to the heart is reduced. Don’t ignore recurring upper body pain just because it’s not in your chest. It might be your heart asking for help.
4. Nausea or Indigestion

That queasy stomach you think is food poisoning or acid reflux could actually be linked to your heart. Nausea, indigestion, or even vomiting can be subtle signs of a heart attack, particularly in women. It’s not uncommon for these symptoms to show up without any chest pain at all.
Your digestive system and heart are closely connected. When your heart isn’t pumping well, it can affect how your stomach and other organs receive blood. Plus, the vagus nerve, which connects your brain to your gut, can play a role in both heart and digestive symptoms. If you’re feeling off, especially with other signs like lightheadedness or fatigue, don’t write it off as just something you ate.
5. Swollen Feet or Ankles
A little puffiness after a long day on your feet is normal. But persistent swelling in your ankles, feet, or even legs? That might be more than fluid retention. It could mean your heart is struggling to circulate blood efficiently. When the heart weakens, blood backs up in the veins, causing fluid to leak into surrounding tissues.
This condition, called peripheral edema, can be an early indicator of heart failure. It usually worsens throughout the day and improves after resting with your legs elevated. If you also notice weight gain, fatigue, or shortness of breath, these symptoms may be working together to tell you something important about your cardiovascular health.
6. Irregular Heartbeat or Fluttering Sensation
That weird flutter in your chest might seem harmless, maybe even easy to ignore. But a racing or irregular heartbeat, especially if it happens often or lasts more than a few seconds, could be a sign of atrial fibrillation or other arrhythmias. These electrical misfires in your heart can increase your risk for stroke or heart failure if left untreated.
Sometimes, it feels like your heart is skipping beats, thumping too hard, or pounding unexpectedly. Stress and caffeine can play a role, but if it keeps happening or makes you dizzy or lightheaded, take it seriously. A heart that can’t keep a steady rhythm may not be pumping blood effectively, which puts pressure on the entire cardiovascular system.
7. Mild Chest Discomfort That Comes and Goes

The classic heart attack image involves someone clutching their chest in agony. But in real life, chest symptoms can be far more subtle and more common than you’d think. People in their 40s and 50s often describe it as pressure, squeezing, or a feeling of fullness that comes and goes. This isn’t always a full-on emergency, but it can be a major warning sign of coronary artery disease.
Sometimes, it only shows up during stress or physical activity, then fades when you rest. That pattern is typical of stable angina, which occurs when narrowed arteries limit blood flow to the heart. Don’t assume it’s heartburn or anxiety if the sensation keeps returning. Your body could be waving a red flag you shouldn’t ignore.